Out of what I have, my Winchester M70 Extreme Weather Stainless with Leupold VX-3i 3.5-10x40. I don't intend on ever hunt Grizzlies and I think it's about perfect for mountain game, caribou, and moose. Maybe on the light side for a big alaskan bull moose but I haven't gotten the chance to shoot anything but Caribou up here. I prepared myself to be capable out to 500 but both bulls I shot were 125 and in due to terrain. I'm no expert on Alaskan hunting but I'd say two would be my unhappy minimum for all big game. The .270 as mentioned for Caribou and Mountain Game and probably a fast handling .338 WM or .375 for the rest. My .375 is a Ruger No.1 or I'd include it.