this discussion reminds me of the old "one shot stop" discusions regards handguns. While handgun use does not usually involve things with teeth sometimes a person has found a need to use one of them under very stressful conditions to prevent themselves from getting killed. I will never see a grizzly in my life, so my opinions don't really matter, but I am curious maybe one of the people who has actually killed a charging grizzly at close range can answer me this? If you have a gun in 30-06 that you can shoot and hit with and you don't piss or crap your pants but instead are able to shoot and hit, then how can a 220 grain .308 caliber Barnes bullet shot clear thru a bear be less effective than a 300 grain .37 caliber Barnes shot shot clear thru the same bear? A hole is a hole, I can see a problem if one does not shoot all the way thru the animal but if both do then a hole is a hole, one should stop/kill as fast as the other.