Alot of the "experimenting" with various cartridges I think is all about trying new stuff and keeping it interesting. My 25-06 kills deer so well because it is accurate and easy to shoot, therefore, the bullets typically find their intended mark. same for my kids 250-3000, they are 6 for 6 with that one, all one shot kills. they are not afraid to shoot that rifle. still, I think the benchmark for comparison in big game rifles is the 30-06 with 180 grain bullets. some better for some applications but at 100 years old, it's still around for a very good reason.