I have never used a small caliber like the 22-250 but years ago when I only had two center fire rifles I had my 22-250 with me as a back up, I just never needed it. I have seen deer killed with a 223 so I see no problem. My personal feeling is that I would want to make sure that I was using a bullet made for hunting and not an explosive varmint bullet. Although years ago I saw a whitetail shot with an explosive varmint bullet out of a 223 and it went between the ribs and exploded in one lung. The deer spun in circles until it went down. Maybe others can share experience on using an explosive varmint bullet.
