I really don’t understand why people have to use that light a caliber. If they loose a big animal they will cry like babies.
That statement tells me all I need to know. You have never used one, but heard blah, blah, blah.
A poor shot, is a poor shot no matter if it is a 22-250 or 300 magnum.
Shot placement trumps! Plain and simple.
We have used the 22-250 on over 3 dozen deer/antelope, and GASP! even a 222 on about 1/2 dozen.
53gr TSX out of the 250 and 63gr Sierra out of the 222. Never had an issue, but the bullets landed where they were supposed to.