I’ve found through much experimentation that no animal can live with a 2” hole through its lungs. They don’t know or care what put the hole there. Many projectiles are available that will enable even a lowly .224 caliber rifle to put a 2” hole through a lot of tissue.
Pick a rifle. Select a decent bullet. Put it where it needs to go. Caliber and more so headstamp mean less than ever before with modern projectiles.
