I shot two bucks one afternoon (a young 9 point and a older fat 6 point) broke both shoulders on the 6 and lung shot the 9. Neither had any problems giving up the ghost. This was with the 223 Rem and the 53 TSX.
Is the 22-250 enough for deer? I will let you know this fall as I grabbed a Model 7 predator and will bloody it this fall using the Hornady 55 SP.
I expect a full cooler.
GreggH