I had injured my shoulder working in the oil patch. A group of us went to Montana and purchased mule deer doe tags when they had an over abundance. I was using my 22-250 with a 55 sierra boat tail bullet. There were some deer standing on the ridge of a watering hole. Picked out the biggest doe and shot her behind the front shoulder at about 150 yards. I lost her at recoil but the man with me said she took off with the others. He was wrong because she has simply dropped down off the ridge.
It was a super clean deadly shot but I didn’t choose the 22-250 as a deer rifle based on that. As a matter of fact I hunted with mainly 30 caliber for about 50 years and dropped one this year at 560 yards with a 308.
My suggestion is to use what you feel comfortable with. Edk