Originally Posted by Pinnah
For those who hunt with .224 caliber bullets, based on your experiences, would you be confident taking a 200 lb deer on a quartering shot?

If so, with what sort of bullet and at what impact velocity?
Yes
The answer would be the same whether the bullet is 22 diameter or of larger bullet diameter. Use a bullet that will penetrate sufficiently, driven at velocities where it will open up at the ranges in which one intends to shoot. If I was planning on regular azz shooting I'd probably use a Barnes.