Back in 2000, I was recovering from a neck fusion. I shot 220 Swift with a muzzlebrake (at my wife's insistence!) and the then available Federal Premium factory 220 S using the 55gr Trophy Bonded Bearclaw. Shota mule deer in Utah, and down in Texas shot an axis doe, and two nice BlackBuck antelope. Only issue I had was the wind blew that little blunt Bearclaw around like crazy! That's my only complaint. My older girl cousin has used the 22-250/33 sp factory for SE Texas deer for decades. Small deer, usually shot off corn feeders up close anyhow. We were all raised by Great Depression Survivor Dads that were adverse to wasting any meat, at all! ha. I personally knew grown men ( when I was a 30-30 users as a teen) who laughed at my Big Gun while they used the 22 Hornet, .222, and then the Nam Vets used the Ruger Mini 14 on everything!