...160gr Nosler partitions in the .270 will get the job done.
Leopard, small hole in, nickle sized hole out DRT.

...Kudu, wildebeeste, warthog, zebra, sable, springbok, blesbok, impala, and a bunch of baboons. All killed with the .270 and Nosler bullets.

I've killed giraffe, zebra, bushbuck, and duiker with the .375, but no DG. If a .375 is your DG gun of choice, load those Swift A-Frames, and go kill stuff.