I'll probably draw lots of flack for this next statement, but for me, the 270/375 is a marginal combo...key words there are "for me". They are both adequate but neither offers much power to spare for many of their intended targets. A 300/416 combo or the 338/416 is far better in my own experience as it offers some extra bullet weight and power for the times when a bad angle shot is all that's offered. Africa is too far, too expensive and too much trouble to use "marginal" type rifles...unless these calibers are all that a person can handle effectively. Thankfully I am not in that category.