While I would not be totally happy with the 375 as the big rifle in this combo, it will work under all the conditions and deliver the results you want with less recoil than the 416. The 270...as much as I love it I would rather have a 30/06 for general bushveld hunting. No disadvantages for recoil or trajectory and not a ton of difference in effect but what little advantage there is lies with the 30/06. Larger diameter bullets that weigh more just work better, in my experience. I love both calibers but unless I'm hunting in really open country I seem to grab the '06 more often than the 270.
