If we start comparing the 10mm - or any other handgun - to a rifle for hunting, as Craig C seems to be doing, the handgun loses. It has less velocity and energy, and is more difficult to place a precise shot with. These are simple facts. Comparing the 10mm to other handguns, however, is different. The 10mm has power and fire-power, and at handgun ranges, when shots are placed well, should do a good job on most medium and a lot of large game. As Mackay said, you have to hit the animal - and hit it well - and at times rapid follow-up shots can be very helpful, without getting into a "spray and pray" mindset.
