This is a chart that I copied from gundata.org comparing 130 and 150 gr bullets. Both are Hornady SP Interlocks.

Naturally the 150 will drop farther but you have to compensate for either one. You have to know what the drop is so you only need to know different numbers. If you want to shoot at 300 yds, it's only a matter of remembering 11" or 13". You still have to compensate for drop.

However, the 150 will be packing more energy at any range beyond 50 yds. The difference isn't much but on a less-than-perfect hit, it can make the difference.

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