A 6.5 cm with 143 horns works from 0-500 and is real neat. What happens if led gets banned? The small cases at modest velocities work real nice with high BC lead bullets but they lack the horsepower to push monos fast enough with a high enough BC for longer distance. I shoot the 127 lrx in my 6.5x47 at 2920fps and that sure isn't as nice as shooting the 143 eldx and if the mono was all I had I'd not be happy with it as a do all 0-500 package. I think the 143 eldx makes sense in the smaller 6.5s as long as you can hunt with it and the idea of one rifle works. If you have to use monos I feel like you need a bigger case if you are looking for one rifle only.