Those things definitely affect WHERE the bullet hits, and you have to factor in the Indian/arrow argument if you're going to break it down in depth...but that does not negate the simple fact that it's what bullet, where, and how fast. And if you want to make the argument that the Grendel can't deliver past 200 yards, you'd be making a very silly statement. It has its limitations for sure, but it sure isn't limited to inside 200 yards if you're using the right components, a decent rifle, and can shoot.
