A 12ga shotgun is capable of anything on the Planet with the correct load. It may not always be the best choice.
But with a 50cal Sabot Solid Slug I could shoot any of the Big Five, but with any Centerfire Rifle I could not shoot Bobwhite Quail Quail on the fly.
Yes the versatility of a 12ga is unmatched.
The Sectional density for the 12 gauge sabot slugs is about 1/2 of what is recommended for dangerous heavy game. I would make sure you have your affairs in order before that safari.
