With the .270 you can can shoot the 130's and 140's fast and flat for about 350 yards with a b.c. of over .5 for the 140's in a 1 in 10 twist. If you want to reach out further than that you use an 8 twist and shoot the 165's, 170's with a much higher b.c. or the longer 140's that require an 8 twist and have a bc of around .620. The .270 case is big enough to hold around 62 grains of slow burning powder to push those heavy's at a reasonable velocity. And of course there's the 150's for excellent penetration. Now if none of those options kill enough, you go to a bigger case, or a bigger case and jump to .338 and use 250's or copper 225's, or even 300's if the case is big enough.