Sierra bullets generally have been accurate for me and usually kill quickly, but often make mess especially with combos like the 180 gameking out of a .300 Win mag and an average mule deer. Shoulder or behind the shoulder, my experience is that high velocity and sierra's equals an exploding bullet. I don't use them anymore. I've seen plenty of shards of copper and lead throughout the body cavity, and the heart is often mush. If you're good with that, then rock on with Sierra's.

I think a lot of the "good" or "bad" experiences concerning these bullets are determined by what one deems as "acceptable" meat damage.