yeah, i started this thread to answer what in my gut i already knew - the bullet is more important than the caliber or the head stamp, provided I keep it reasonable (243 and above). Bigger diameters make sense in certain situations... for example hunting black bear (fat can plug the hole and leave a poor blood trail)...

I am really trying to talk myself into leaving the 7mms and 30s in the safe and use a .25 for an all-arounder for anything not in thick cover (where I could lose the blood trail). I suppose the smaller diameter rifles work well until they don't.