Wind can be an issue. One could make a case for a round like the 26 Nosler. It shoots high B.C. bullets pretty fast. Of course, the quicker the bullet gets there, the less time wind has to create havoc.
I'm not a fan of 500+ yd. game shots, but if that's the only shot I was gonna get at a trophy, all or nothing, I'd feel pretty comfortable with my 26 Nos, a good bullet, Z3 BT twisted to the determined range, as solid a hold as I could come up with and BANG...
No substitute for lots of practice, but good equipment does offer an edge.
