Well, there's hardly much difference when you use monos between the performance of .22 caliber 53 grain bullets and 180 grain 30 caliber bullets on deer. The holes look about the same and the bullets go all the way through all the time or very nearly so.
A 30-06 with 130 grain monos will work nicely on any NA game. It's mild. A 270 with 110 grain monos will do the same and be virtually indistinguishable from the '06 in terms of recoil/muzzle blast. A 243 with an 85 grain TSX at 3450 (4451) surprised me that it was so much like an '06 with 130s last week. I doubt I'd choose a 243 for shooting big bears as a first choice, but I have no doubt it'd work if it had to.
It comes down to what bullet and how fast do you push it in today's world.
