I'd be more concerned about the platform and the bullet than I would be the caliber, within reason.

Id guess 243 would certainly work, but I'd be more inclined to 270/280, 30/06, or even 338 WM type rounds. Maybe a 9.3 or 375 if it was in a special rifle I had to take.

“Life is life and fun is fun, but it's all so quiet when the goldfish die.”