I'm just back from Zambia and while I took two rifles, I shot everything with the 375 and 270 grain A-Frames.
From 20 pound grysbok to 4500 pound hippo, everything took only one shot. The buff got an extra, un-needed second shot to keep him from following the herd.
This is actually about the third successful trip in a row where the 375 gets all my business! Sometimes I'm a slow learner!
Oh, and the leopard was dead under the bait, so apparently the 375 works on cats too!