I always err on the side of bullet weight, diameter, momentum and penetration, too many things can happen to only rely on surgical placement.
As much as a hunt cost and the time invested makes me want to have more than just enough gun, but one that I can shoot well, have all the confidence in.
That gun, in this case, would be my NH M-70 SS .375 H&H. It's chopped, flutted with NECG irons and a Victory 1.5-6x42 glass. It's slick and it shoots. I'd work up some good loads and go hunting.
DF