The eland I shot in Zimbabwe went down immediately with a 300 grain .375 TSX. Seems like a good choice to me, based on my one experience with eland. My experience also mirrors Mule Deer's comments about long tracking. A rifle that's a bit lighter than my CZ 550 would be nice for extended tracking. On the other hand, the extra weight does reduce recoil and makes a .375 easier to shoot and hit with, at least for me. The nice thing about a .375 is that it can handle nearly anything you might encounter, and in Africa you never know what that might be.