No claim to extensive experience but on four elk (two bulls and two cows) at ranges of ~100 to ranged 300-340 all exited for me fired from a 7MM STW with muzzle velos of right around 3,300. I have shot numerous Kansas deer at 75-300 as well with all exiting. I would never have any doubts that they will get the job done and like mentioned before I don't see any more drastic damage than with most bullets fired at fairly high velocities. YMMV
