@moosemike, I will be moving to the Lancaster, PA area. So my thoughts regarding options are: Use 223rem with "good deer" bullets, download 308win, or rebarrel my 308win to 6.5creedmoor or 243win.
Welcome! I'm one county to the north.
An uncle of mine, in Dauphin and Northumberland County, did all his deer hunting for decades with a .22 Hornet. Vast majority were one shot kills.
I had a guide back in the 80's who lived in Laramie, WY, who for many years filled his personal mule deer and antelope tags with a Winchester M43 .22 Hornet, iron sights. Not a lick of finish left anywhere on that rifle- from years of riding uncased in the bed of his pickup.
When I run into guys here in our Maryland woods toting .300 Magnums (and bigger) I just smile, compliment them on their fine choice of whitetail deer rifles, and walk away thinking about Elmer Fudd for some reason. It seems that I run into at least one guy like that every year.
