Two years ago, I had the opportunity to autopsy 3 Newfoundland bull moose, all shot twice, broadside through the lungs/heart. Results were nearly identical, all 6 bullets were found under the skin on the far side. All were mushroomed perfectly. All went down within a few feet of being hit with the first shot. First moose was taken with 150 gr Partitions out of a 300 Savage at about 65 yards. Second was taken with 180 gr Trophy Bonded out of a 300 Win Mag at approx 200 yards. Third one also used 180 gr Trophy Bonded, but out of a 300 Weatherby, also at about 200 yards. FWIW, this past season, I watched a Maine bull moose get hit, broadside through the liver at about 300 yards with 200 gr Partition out of a 8mm Rem Mag. He walked 15-20 ft and went down. Got complete penetration with that bullet. The liver was thoroughly destroyed. My take away is that the only important thing is to tuck a good bullet into the right spot.
Imagine your grave on a windy winter night. You've been dead for 70 years. It's been 50 since a visitor last paused at your tombstone..... Now explain why you're in a pissy mood today.