Hunted cow elk in central Montana last two years. No grizz in area. Last fall a hunter shot a cow at about 200 yards with a .243 using 100 grain Hornady bullets. Shot twice but probably did not need to shoot second time since both shots were in same place. Animal fell near shot impact. Another hunter was using a .375 H&H with TTSX bullets. Shot six times, hitting animal 5 times at about 100 yards with animal standing and not running. Animal finally fell over after last shot and all shots should have been lethal within a few inches of each other. Bullet selection and shot placement is probably more important than caliber, based on this example of one.