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I would like to add/share what I have done with the .375 Ruger.

I have an Alaskan with 20" barrel and Hogue overmolded. I have milled off the bolt knob, threaded it, and installed a larger aluminum knob to facilitate my lefty use of a righty rifle. It sports a Leupold VX-6 1-6x24.

All data taken from my strap-on chronograph.

Buffalo Bore 270 gr TSX
1. 2687
2. 2763
3. 2748
4. 2758
5. 2758

SD = 31.67
ES = 76
AVG = 2743FPS


Hornady 300gr DGS
1. 2479
2. 2456
3. 2470
4. 2448
5. 2469

SD = 12.3
ES = 31
AVG = 2464FPS


Handload - 79.8gr W760, CCI 250, Hornady 270gr SP-RP
1. 2702
2. 2707
3. 2732
4. 2702
5. 2727

SD = 14
ES = 30
AVG = 2714

Quickload predicted 2611FPS, so I apparently have a "fast" rifle.

I started with RL15 in 2019, then could not find any, so switched to W760. Just bought another 8lbs./700 rounds worth.

I detailed the use of the Buffalo load in RSA via my safari report. The TSXs did a great job! The Hornady's are less expensive and are fine for deer in MO where 75 yards is a long shot.