Hopefully you have better luck with the 375 ruger than I did. I couldn't get h&h velocity out of my 23" 375 ruger barrel without the bolt sticking(that was with any bullet). Other's seem to be getting good velocity though in the 375 ruger.
The 270 TSX has been the most accurate bullet I've shot out of any 375. My top accuracy came with RL15 powder near max and seated to the bottom edge of the first crimp groove. That combination in the 375 h&h and ruger(20" & 23" barrel) both gave me 1/2" groups at 100 yards when my trigger pull was right on. I haven't used the bullet on anything but deer, but is did expand in deer and left about a 50 cent piece exit on the deer without hitting any bone.