I am a big fan of the 375 Ruger, and also the 416 Ruger. The older 20" Alaskans with aftermarket stocks and a little trigger smoothing or replacement are in the top few of my favorite rifles.
The 375 Ruger cartridge is certainly my favorite.375.
I might be stuck in the Stone Age as to powder choice. I have been using H380 with the 270 grain TSX since Barnes published the data. No complaints as to velocity nor the accuracy. This past year I have loaded the 270 grain LRX with it at a bit longer COAL than Barnes. Seems to work well with it also. I have not been motivated to try other powders. Though it seems there are several other good to excellent choices.
