I shot one that weighed about 350lbs 27 years ago on the Hunt river near Ambler with a Remington 788 22-250. I ended up killing it with the first shot at about 150 yards with a neck shot. They are much smaller than the bears where Phil is at. Tyler Freel shot a huge interior Grizzly this Spring with a 6.5 Creedmoor. I had students kill one while I was up in Ambler with three 10/22 ruger rifles in 22LR. They shot the bear about 40-50 times. Heimo Korth has shot probably north of 40 Grizzlies with a 22-250 in another Remington 788. He prefers a Slug gun today. I killed another grizzly DLP with a Ruger Super Blackhawk in 44 Mag when I was 18 years old fishing on the Tonsina River. It had been injured with an illegal snare and was in bad shape. I like bigger caliber rifles now. People have killed bears with 250-3000 and even 32-40s and believe it or not 25-20s.