I'm going on my 3rd grizzly baited hunt with Jake Jefferson in June. My 1st grizzly was a nice sow killed with1 shot from a 375 Ruger with 270 Hornady factory interlocks. The 2nd grizzly was also a sow 1 shot kill with a 30/06 with 220 grain Nolser partitions handloads. Both went about 20 yards. Jake has killed grizzly with a 270 when he was young. I know his wife & 2 sons have killed 8 1/2 ' ers with a 308 Winchester. All of these bears were taken @ 100 yards. 1 shot kills. Shot placement is critical. For my hunt this June I'm taking back the 30/06----I'm thinking either 180 Hornady round nose interlocks----which is my do everything load here in the lower 48. Or maybe 220 grain factory loads either Federal or Remington. Bob