Guess I've been lucky and never really got surprised...
Have slowly worked my way up to heavier kicking stuff. I always thought I wanted a 450NE or 458 Lott, but currently have a Ruger 1-H in 450-400, unscoped with 400 Woodleighs. With full power loads, I think I've reached "enough". Funny thing is, it's a pussycat around 1900 fps. 2000 ain't bad. But 2170, off the bench, it makes my joints ache for hours. May get around to scoping it and having a decent pad put on it.