Gee's another tastes great less filling thread! The cartridge is nothing more than a launcher for the bullet, a good bullet regardless of size or weight that is reasonable is going to put game on the ground, if you can put that bullet in the right spot. Be it 243 or a 338 or anything in between. There are two issues here recoil, and over all rifle weight and fit. And then there is the Hunter/rifleman him or herself. Most will shoot a 270 for example better than a 300 Winnie or the like, and such rifle can be a tad lighter so one can carry it all day for a week or two. This stuff is not rocket science, for most of us big game hunting means White Tail Deer hunting, and with that anything from a 223 to a 30-06 is going to put venison in the freezer. Africa is for most a one time deal, so is Elk, Moose and sheep. As for shooting distances, do what you want to do and leave it at that. As for the cartridge in question, its dam hard to improve on!
"Any idiot can face a crisis,it's the day-to-day living that wears you out."
