I've used 250 gr. bullets for 90% of my hunts with a Whelen, Shot a bunch of elk, and a few moose and caribou with them. 2500 FPS is fast enough for me, and I get that speed with RL 15 and formerly used IMR4064. I really like the discontinued Speer Grand slams but have had very constant results even with the standard Speer and with Hornady interlocks.