I get all I need with 57.5 gr. Re-15 and a 250 gr. Partition. It shoots just as good with 250 gr. speer, 250 gr. hornady or 250 gr. grand slam.
The biggest thing I have shot with it is a 1100 lb. bison. took 2 steps and laid down and died. I would use it for anything including big bears and not feel undergunned.
It do kick in a remington with plastic stock.