The last big buck I killed with my 243 already had 3 100 gn core lokts in him when I shot him in the neck. He laid down and got back up. 5 th bullet under the ear turned him off and I never used the rifle again.
The year before I killed a big buck with it and put 2 through the.ribs and one in the jaw running. He went a 1/4 mile into a bad place to drag one from.
I use bigger bullets now and don't have that problem any more.