Another 243 fan here, I've never had an issue. I've used the 80 GMX, 80 TTSX, 105 HPBT and 95 NBT. A friend has killed an absolute pile of deer with the 100gr Federal Blue Box and 95gr Fusion. We hit them in the important parts in the front end, I'm a shoulder breaker, and we've never had an issue. I've actually never recovered a bullet from my 243's as all have passed through. I'm a thick woods hunter so I take whatever angle I have in order to get to the vitals.
