Zero issues with deer hit with well-placed 243 bullets. If you're hunting them "afoot" and taking the angles that are given by obstructions... maybe sometimes the answer is just not to shoot... rather than depend on a bigger bullet to make up for placement. That's not a criticism of how anyone hunts or what with... just an observation.
I've killed several deer with 100 grain CLs in 243. None of them went anywhere. On the other hand, I shot a deer a few years ago at about 50 yards with a 6.5mm bonded bullet, turned both lungs and the heart to liquid, but the damn thing still ran 40 yards into the thickest stand of blackbrush in Texas before hemorrhaging (looked like the bucket of blood scene from Carrie) everything in the chest cavity and falling over. Sometimes deer are just gonna run dead on their feet.
There's certainly nothing at all wrong with taking angle/quartering shots that go through vitals. If you're worried about a 40-50 yard death run making a deer "nearly impossible to find" you should probably stay in your stand where you can pick your shots.
