Having recently moved to Florida, I am amazed how many people use a .22-250 for whitetails. Of course the Whitetails are much smaller down here. I thought it was marginal but the 3 of them I have seen taken did not take a step. Maybe something to do with the velocity and the shock. They all were using standard 50-55 grain loads. I was amazed at the performance. Put it in a robust stock, get a good recoil pad and you won't feel a thing.