Some folks cannot handle the larger recoil. Just a fact of life. Some are much more senstive. Some get sensitive as they get older.
Its all about shot placement in the end, as long as it has enough power and the right bullet is chosen.
My guide buddy stopped I can't recall how many of the rascals with a measly 338... thats not supposed to happen.
Generally when it comes to what to bring, as long as its "enough" then I'd just as soon you pick a good bullet and bring a rifle you can shoot if you go with me.
That minimum caliber varies from game to game obviously....
We can keep Larry Root and all his idiotic blabber and user names on here, but we can't get Ralph back..... Whiskey Tango Foxtrot, over....
