If the higher BC projectile happens to offer all the required #4 OTP, (and there are bullets that can and do that for some people), that person can pass on NPs and not be at a loss.
Take the popular 300win- If someone thinks they lost their prized elk because they didn't use a 200NP or 220NP instead of the 210 LR-AB then I would be inclined to put it down to poor shooting than poor choice of bullet.
-Bulletproof and Waterproof don't mean Idiotproof.