If we're talkin' target rifles here, sure, sign me up with a .243.
If you're lookin' for velocity enough for expanding a hunting bullet, there isn't a nickle's worth of difference in a .25-06, or a .243 of the best stripe (might be an advantage for the .25 caliber in fact - with the Weatherby). One eats a little less hay, and requires a slightly smaller blanket. That advantage goes to the .243's.
