Maybe an action issue too. If I was itching all over for a .25, I'd pick the cartridge that best fit my action of choice. In a single shot, some thought would be given to barrel life and availability of good brass and/or ammo too.
All things considered, my 6mms make the most sense for me right now. I can shoot 115s out of my Creedmoor if I feel a need.
Well, some [bleep] had to bring up the creemoooore in this thread. Heaven forbid its not mentioned for a couple hours.