Most here have more experience than I, but a couple of points:

With Remora holsters, do not forget you are wearing them when you go to the bathroom. You loosen your belt, you drop your gun.

A lot of folks have talked about making some pretty radical changes in gun form factor. I have always tried to avoid picking guns that require different training and muscle memory. All of my carry choices follow the 1911 layout. The safety and magazine release are in the same place, so all practice drills are the same, whether it is a Browning Huntsman (not a carry gun), P238, or full frame 1911.