They might work pretty well, especially at typical 2650-2700 fps muzzle velocities.
A long time ago I was using the 165 Hot-Cor in a Remington 760 .30-06 for whitetail hunting, loaded to around 2800 fps. Killed an angling away, running buck at around 100 yards. The bullet entered the rear of the ribcage on the left side, and ended up in the right shoulder--retaining 85% of its original weight.
